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Clinical Studies:

Products:

 

IMPERMEABILITY
Study

TABLE OF CONTENTS:

Purpose of Study:

Demonstrate ability of the Hand Sanitzer Lotion with Invisicare to act as an effective barrier to noxious agents.

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Testing Laboratory:

APPLIED CONSUMER SERVICES, INC. (ACS)

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Protocol:

An impermeability study was conducted under in vitro laboratory conditions using a gravimetric method to determine levels of challenge liquid passing through diffusion chambers separated by a fritted glass membrane coated with an Invisicare formulation.

In the first study, twenty-eight (28) different toxic agents representative of a chemically diverse group of solvents, acids, bases, dyes, insecticides, herbicides and hydrocarbons were tested for their ability to permeate the Hand Sanitzer Lotion with Invisicare.

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Results:

  • In all cases the Hand Sanitzer Lotion with Invisicare resisted permeation by all tested substances.
  • In all cases permeability exclusion exceeded 99% except for the following:

    • 100% gasoline (96.7 % / 96.6%)
    • Methylene Chloride (28.6% / 31.8 % )

Note: Additional clinical studies measuring Trans-epidermal Water Loss (TEWL) and Corneometer measurements show that Invisicare exhibits selective impermeability required to allow for normal respiration and prevent hazardous environmental challenge.

 

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Table 1:   Summary of findings from Challenge Liquid Impermeability Test

Test No. Chamber A Challenge Liquid Receiving Chamber (H2O) 3 Hr / 6 Hr Conc. Percent Retained in Original Chamber
1 16% Acetone 0.18 % / 0.47 % 99.9 % / 97.1 %
2 10 % Formaldehyde 0.04 % / 0.07 % 99.6 % / 99.3 %
3 5 % Ammonia 0.02 % / 0.04 % 99.6 % / 99.2 %
4 5 % nAc1O (Clorox) 0.09 % / 0.12 % 98.2 % / 97.6 %
5 3 % Hydrogen Peroxide 0.036 % /0.060% 98.8 % / 98.0 %
6 10 % Conc. HC1 (38) 0.005 % / 0.009 % 99.9% / 99.8 %
7 10 % Sodium Hydroxide 0.04 % / 0.07 % 99.6 % / 99.3 %
8 1 % Baygon 0.005 % / 0.007 % 99.5 % / 99.3 %
9 1 % Malathion <0.01% / <0.01% >99% / >99%
10 1 % Dursban/ Chlorpyrifos <0.01% / <0.01% >99% / >99%
11 1 % Diazinon <0.01% / <0.01% >99% / >99%
12 1 %Atrazine <0.01% / <0.01% >99% / >99%
13 100 % Perchloroethylene 0.670 % / 0.673 % 99.33 % / 99.33 %
14 100% Methylene Chloride 28.6% / 31.8 % by vol. 71.4 % / 68.2 %**
15 100 % Gasoline 3.3 % / 3.4% PPM 96.7 % / 96.6 %
16 100 % Diesel Fuel 2.1 /2.1 PPM 99.99 % / 99.99 %
17 100 % Paint Thinner <1 / 27 PPM 99.99 % / 99.99 %
18 100 % Paint Stripper 7.7 / 37.0 PPM 99.99 % / 99.99 %
19 6 % Latex With Protein <0.005 % (4hrs) > 99.92 %
20 1 % D & C Red 33 9.8 / 20.9 PPM 99.90 % / 99.71%
21 1 % D & C Green 28 <10 / <10 PPM >99.90 % / >99.90 %
22 1 % D & C Green 6 0.037 / 2.53 PPM 99.99 % / 99.97 %
23 1 % D & C Yellow 5 18.4 / 45.9 PPM 99.82 % / 99.64 %
24 1 % D & C Red 4 1.86 / 14.8 PPM 99.88 % / 99.85 %
25 1 % D & C Red 40 0.019 / 8.50 PPM 99.99 % / 99.91 %
26 1 % D & C Blue 1 2.98 / 10.48 PPM 99.97 % / 99.90 %
27 1 % D & C Red 3 14.8 / 22.68 PPM 99.85 % / 99.77 %
28 100 % Wax Stripper 84.7 / 226 PPM 99.99 % / 99.98 %

Note: This document is an excerpt taken from Chapter 4 of the "Report of The Scientific Advisory Committee on The Skinvisible Line of Products".

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